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MBBS QUESTION #10369
Question 1
A mutation that converts a codon normally specifying an amino acid into a premature stop codon, prematurely truncating the resulting protein, is termed a:
  • Missense mutation
  • Nonsense mutation✔️
  • Silent mutation
  • Splice site mutation exclusively
Correct Answer Explanation
A nonsense mutation introduces a premature termination (stop) codon, halting translation early and typically producing a truncated, often non-functional protein — as seen in some forms of beta-thalassemia and cystic fibrosis.