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MBBS QUESTION #10222
Question 1
Apoptosis differs fundamentally from necrosis in that apoptosis is best described as:
  • A programmed, energy (ATP)-dependent process of cell death that does not provoke a local inflammatory response✔️
  • An unregulated, passive process always triggered by ischemia and always associated with inflammation
  • A form of uncontrolled cell swelling and membrane rupture
  • A process identical to necrosis but occurring only in cancer cells
Correct Answer Explanation
Apoptosis is an active, ATP-dependent, genetically programmed form of cell death characterized by cell shrinkage, chromatin condensation, and formation of apoptotic bodies that are phagocytosed without spilling cellular contents — hence no inflammatory response, unlike the passive, inflammation-provoking process of necrosis.