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MBBS QUESTION #10191
Question 1
Transposition of the great arteries results from an abnormality in which developmental process during heart formation?
  • Straight (non-spiral) partitioning of the truncus arteriosus by the aorticopulmonary septum✔️
  • Failure of closure of the interventricular septum
  • Failure of fusion of the endocardial cushions
  • Abnormal development of the sinus venosus
Correct Answer Explanation
Normally the aorticopulmonary septum spirals as it divides the truncus arteriosus, positioning the aorta and pulmonary trunk in their crossing relationship. When this septum forms straight rather than spirally, the aorta arises from the right ventricle and the pulmonary trunk from the left — transposition of the great arteries.